Hypogonadism

What Causes Testosterone Levels in Men to Go Down According to TRT Australia Doctors?

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As men grow older and they advance in age, the natural tendency of their testosterone is to decrease as well. The aging process is inevitable, and scientists found out that it is directly related to the male human body’s slowdown in the production of testosterone. Hence, low T occurs. 

 Experts believe that around 40% of men who are in their 40s will go through a gradual decrease of testosterone in their system. However, what is considered more scarce is the deficient testosterone levels. This can happen due to many reasons. 

 Before anything else, we need to define what low testosterone is all about.  

What Is Low Testosterone?

 Testosterone is the male sex hormone. It has a central role to play in the development of the male human body during the puberty period. It is also one of the hormones that are vital to male fertility. Produced in the testicles, this hormone is also responsible for the production of sperm. Testosterone levels are low if the male body system is not able to produce enough of this hormone for its own. 

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What are the Indicating Signs of Testosterone Deficiency?

 Men suffering from a testosterone deficiency can experience the following symptoms. These symptoms may include erectile dysfunction and constant fatigue. A patient would sometimes complain about the difficulty in conceiving a child with their female partner/espouse.  

 There are also occasions when medical professionals are challenged with identifying the indicating symptoms for low-T. It is because they are similar to the symptoms of other medical conditions. This means to say they have some parallelisms to other illnesses, therefore careful and more thorough evaluation/test should be carried out to the patient.

Testosterone deficiency symptoms may include the following 

  •  Erectile dysfunction
  • Infertility
  • Low muscle mass
  • Depression
  • Drastic changes in mood
  • Fatigue

What Causes Low Testosterone?

sports and fitnessDo not get confused if you encounter the words hypogonadism and testosterone deficiency syndrome. They refer to the same condition, and that is to describe T-levels that have dropped. 

 Studies have shown that there are a handful of men out there who have lived their lives with low testosterone levels. But others tend to develop the condition later in life.  

 Hypogonadism is a combination of suggestive symptoms of low testosterone and low T-levels on evaluation. We can classify it into two main categories, primary and secondary.  

Primary hypogonadism can be hereditary. It may take place following an injury to the testis or after some illness. The problem is testicular. This means to say that the testis is not capable of producing enough amounts of testosterone. This condition can be induced by:  

  • A high concentration of iron in the male human body
  • Klinefelter syndrome
  • Testicles that fail to descend at birth

 In the case of secondary hypogonadism, this usually happens when some sections of the male human brain, like the pituitary gland (which is responsible for the production of the hypothalamus), the hormone that regulates other hormones — get damaged.   

Indicating symptoms of secondary hypogonadism are 

  •  Autoimmune diseases
  • A high concentration of body fat
  • Age

Treatment of Hypogonadism As Suggested by TRT Australia Doctors

It is such a relief to know that we now have a variety of treatment options for hypogonadism. At-risk here are men who happen to have type 1 or 2 diabetes. 

If you are showing signs of low testosterone, TRT Australian doctors will carry out a series of blood tests before they prescribe you any kind of treatment.  

Topical treatment is, so far, the most common option. Alongside this option are creams, gels, and patches. They all deliver testosterone into your bloodstream. Other options to consider would include implantable pellets and injections.  

 

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Why TRT Perth Doctors Believe That Low-T Levels Undermine Men’s Immune Response to COVID-19?

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Testosterone replacement therapy doctors in the country have a good reason to believe that low concentration of testosterone in older men’s systems could predispose them to a not so pleasant COVID-19 outcome. And there is a good possibility, too, that this could be the underlying reason, the missing link, why there is a higher fatality rate of coronavirus cases in men as opposed to women.

According to  Conversano Hospital head of outpatient endocrinology clinic in Bari, Italy,  Vito A. Giagulli, MD, Ph.D., men naturally have in their system that biological predisposition to become ill due to COVID-19.

This can stem either from their high plasma testosterone levels as opposed to women, or from age-associated low-T levels. Considering also that low-T level is a crucial frailty parameter, it would pave the way for severe and likely very fatal COVID-19 infection among men.

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Disparity in Outcomes

Relevant data on COVID-19 cases gathered from around the world reveal that both sexes, men and women, are equally prone to contract the new novel coronavirus. This is the virus species that leads to COVID-19 disease.

However, the number of patients being admitted to hospitals due to viruses that are aggravated by serious clinical events such as pulmonary distress, renal injury, acute cardiovascular injury, disseminated intravascular coagulation, or multiple-organ failure, by virtue of statistics, is much higher for men versus women.

After taking a closer look, TRT Perth doctors and the global medical community are under suspicion that there might be a handful of specific factors that are inducing bias for poor prognosis in men that are affected by COVID-19.

In a review of published related literature, Andrology reported that observational data indicate that patients that come with worse clinical progression – most of the time older adults who happen to have 1 or several underlying chronic diseases – are likely suffering from hypogonadism, too.

Furthermore, the ACE2 or the angiotensin-converting enzyme 2, which is vital for the entry of SARS-CoV-2 into host cells, is also utilized by the male body, particularly in the testes. They also added that the results only goes to show that SARS-CoV-2 may bring about the infection to the testicles, and thus may impact the production of testosterone in younger patients.

So that in cases of more senior men,  or of those men with dysmetabolic diseases such as low serum testosterone level and obesity can predispose them with an impaired response of the immune system. Thus, paving the way for the worst scenario of SARS-CoV-2 infection in men.

A handful of recent studies show that low amounts of plasma testosterone, observed to be a common denominator among men with obesity or older men, including men suffering from other kinds of chronic or persistent diseases,  could pave the way for an impaired CV function, systemic inflammation, thromboembolism and worse outcomes of COVID-19 infection

TRT Perth doctors, together with the global medical community, agrees with the supposition that testosterone itself predisposes men to suffer from having a less effective immune response against infections.

Hypogonadism in men, a condition characterized by diminished production of the male sex hormone, could be the triggering factor for a detrimental cytokine dysfunction. This could also be accountable for why men with COVID-19 are likely to suffer from poor prognosis.

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